Protein Details: Acid-sensing ion channel 2

Protein ID

ICDB_Pro_1131

Protein Name

Acid-sensing ion channel 2

Gene Name

asic2; accn1

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Length

533 amino acids

AlphaFoldDB

AF-Q708S5-F1-model_v4.pdb

Function

Probable cation channel with high affinity for sodium. In vitro; has no proton-gated channel activity.

Sequence

MDLKEACGSEASRETESGGMGSLGGHSSWQSFAHRSTLHGLRFIFPYSSSSSSSSSYRSTSRRLLWSAALLASLVLLVLESTERLAYFLSYPHVTSVDAVVSGSLVFPAVTVCNLNAYRFTRLTQNDLYHAGELLALLDVHLQIPEPHLAEPHVLAFLTEKSNFTNYRPKPFSMREFTERVGHDLKEMMLYCRFQGQECSHQDFKTVFTRYGKCYMFNAAEEGKTLRTTMKGGTGNGLEIMLDIQQDEYLPVWGETEETAFEAGVRVQIHSQAEPPFVHELGFGVAPGFQTFVATQEQRLTYLPPPWGECVSRALDSGLFQVYSVSACRIECETRYIVENCNCRMVYMPGDSPYCTPEQYKDCAEPALAALSAVEGTNCICRSPCNMTRYNKELSMVKIPSKTSARYLEKKFNRSEKYITDNILVLDVFFEALNYETIEQKKAYEVAGLLGDIGGQMGLFIGASILTLLELFDYAYEVVKERLLDLLNREEEEESHGEDVSTCDPVVNHSESISHTVSVPLQTTLGTLEEIAC

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in central nervous system

DOI ID

10.1074/jbc.m401477200

RefSeq

NP_999953.1

Feature